The drive is not ready for use; Its door may be open.Please check drive A; and make sure that a disk inserted and that the drive door is closed.
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Do you have any USB Mass Storage devices (USB HDD, Flash Drive, Card Reader etc) plugged in. Remove these. Boot into Setup (Bios) go to Peripherals. Disable Floppy Seek, and Floppy drive. Go to Boot Priority. Remove Floppy or Drive A: from boot sequence.
Restart the computer and go to Start/Run and type devmgmt.msc and press enter. In the Device Manager are there any devices with yellow flags?
If you have an external HDD plug that into the Back USB port of the computer not the front. Do you now get the message that the drive is not accessible? If so, then this HDD may have failed.
If your PC does not have a floppy-disk drive, go into BIOS Setup & disable it.
If you do have one, replace with a new one.