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Trying to install MS-DOS 6.22 on a flash drive, then from this flash drive use it to install MS-DOS 6.22 on to HDD connected through USB ports.
My Bios does have legacy support
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Dos doesn’t recognize USB ports and therefore won’t see anything connected to them without the addition of special drivers. There’s some info here:
http://www.bootdisk.com/usb.htm
Does the computer you’re doing the install on have a floppy drive? I assume you have the 6.22 floppy installation disks? How big is the external drive? 6.22 only works on fat16 partitions which can be no larger than 2 gig. Most external drives are going to be much larger so you end up with many logical drives or wasted space.
If your eventual goal is to get 6.22 installed on a hard drive, the easiest way is to connect the drive internally and do a regular install with floppy disks. Can you temporarily remove the external drive from its enclosure and connect it internally? Is it an IDE/ATA drive and not SATA?
You can experiment with the bootdisk.com suggestions and maybe find something that works for you but the easiest way would be to use the traditional installation method.